Mindfulness is a cognitive process in which the mindful person, without judgment and with acceptance, focuses on experiencing the feelings and events that are currently happening in or around him. The aim of this study was to investigate the relationship between mindfulness and depression in kidney patients. For this purpose, a sample of 100 patients with renal failure referred to the Center for Special Diseases and Amir Al-Momenin Hospital in Zabol in the first six months of 2016 were selected. The Kentucky Mindfulness Skills and Beck Depression Inventory tools were used to collect information. The results showed that mindfulness has a negative and significant relationship with depression (p = 0.01). Also, the components of mindfulness each have a separate negative and significant relationship with depression. These results show that increasing mindfulness in people reduces their depression.